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Sove (Zolpidem)

Sove (100 and 500 nM, alpha1 selective) affected the deactivation of a subset of the mono-mIPSCs, indicating that alpha1 subunits are not highly expressed in these synapses. Development and Validation of a Stability-Indicating Capillary Electrophoresis Method for the Determination of Sove Tartrate in Tablet Dosage Form with Positive Confirmation using 2D- and 3D-DAD Fingerprints.

Other names for this medication:
Zolpidem, Ambien, Ambiz, Lipidem, Nidra, Nitrest, Sove, Soza, Stilnoct, Zappy, Zedem, Zleep, Zodem, Zolax, Zoldem, Zolfresh, Zolip, Zolit, Zolp, Zolpi, Zolsoma, Zoltar, Zolway, Zopid,

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Sove comes as a tablet (Ambien) and an extended-release (long-acting) tablet (Ambien CR) to take by mouth. Sove also comes as a sublingual tablet (Edluar, Intermezzo) to place under the tongue and an oral spray (Zolpimist), which is sprayed into the mouth over the tongue. If you are taking the tablets, extended-release tablets, sublingual tablets (Edluar), or oral spray, you will take the medication as needed, not more than one time a day, immediately before bedtime. If you are taking the sublingual tablets (Intermezzo), you will take the medication as needed, not more than one time during the night if you wake up and have difficulty returning to sleep. Sove will work faster if it is not taken with a meal or immediately after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Sove exactly as directed.

You will probably become very sleepy soon after you take Sove and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take Sove tablets, extended-release tablets, sublingual tablets (Edluar), and oral spray and to stay in bed for 7 to 8 hours. Take Sove sublingual tablets (Intermezzo) only when you are already in bed and can remain in bed for at least 4 more hours. Do not take Sove if you will be unable to remain asleep for the required number of hours after taking the medication. If you get up too soon after taking Sove, you may experience drowsiness and problems with memory, alertness, or coordination.

Swallow the extended-release tablets whole; do not split, chew, or crush them. Tell your doctor or pharmacist if you cannot swallow tablets.

Do not open the pouch that contains the sublingual tablet (Intermezzo) until you are ready to take the tablet. To remove the sublingual tablet (Edluar) from the blister pack, peel off the top layer of paper and push the tablet through the foil. To take either brand of sublingual tablet, place the tablet under your tongue, and wait for it to dissolve. Do not swallow the tablet whole or take the tablet with water.

To use the oral spray, follow these directions and those that appear in the package label:

  1. Before using Sove spray for the first time, or if you have not used the spray bottle for 14 days, you must prime the pump.
  2. Line up the arrows on the cap and the base of the container. Squeeze the cap at the arrows and pull the cap and base apart to separate. Remove the clear protective cap from the pump.
  3. To prime the pump, hold the container upright. Point the black spray opening away from your face and other people. Press down on the pump with your forefinger, release and let it return to the starting position and repeat 4 more times. You should see a fine spray come out of the container.
  4. To use Sove spray, hold the container upright with the black spray opening pointed directly into your mouth, over the top of your tongue. Press down fully on the pump to make sure that a full dose of Sove is sprayed.
  5. Let the pump return to the starting position. If your doctor prescribed only one spray of Sove, put the clear protective cap back over the pump at the top of the base after each use. If your doctor has prescribed two sprays of Sove for your dose, a second spray should be used.
  6. Snap the child-resistant cap back onto the base and rotate the cap and base so that the arrows are not lined up. This is to help prevent a child from using the spray mist bottle.

Your sleep problems should improve within 7 to 10 days after you start taking Sove. Call your doctor if your sleep problems do not improve during this time or if they get worse at any time during your treatment.

Sove should normally be taken for short periods of time. If you take Sove for 2 weeks or longer, Sove may not help you sleep as well as it did when you first began to take the medication. Talk to your doctor about the risks of taking Sove for 2 weeks or longer.

Sove may be habit forming. Do not take a larger dose of Sove, take it more often, or take it for a longer time than prescribed by your doctor.

Do not stop taking Sove without talking to your doctor, especially if you have taken it for longer than 2 weeks. If you suddenly stop taking Sove, you may develop unpleasant feelings or mood changes or you may experience other withdrawal symptoms such as shakiness, lightheadedness, stomach and muscle cramps, nausea, vomiting, sweating, flushing, tiredness, uncontrollable crying, nervousness, panic attack, difficulty falling asleep or staying asleep, uncontrollable shaking of a part of your body, and rarely, seizures.

You may have more difficulty falling asleep or staying asleep on the first night after you stop taking Sove than you did before you started taking the medication. This is normal and usually gets better without treatment after one or two nights.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Sove and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( or the manufacturer's website to obtain the Medication Guide.

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These studies require careful planning and sequencing and should be performed in the order of least invasive first, with progression to more invasive studies if necessary. Although robotic-assisted gait training (RAGT) is becoming a standard method in stroke rehabilitation, its effect on chronic stroke patients is uncertain.

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Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF. What are the anatomical predictive factors of degenerative superior labrum anterior to posterior lesion in rotator cuff tear? Recent progress in the electrochemical exfoliation of graphite and prospects for the application of exfoliated graphene, mainly in the fields of composites, electronics, energy storage and conversion are discussed. Mutants of bacteriophage T2 gt with altered DNA methylase activity.

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Venous thromboembolism associated with hip and knee replacement over a ten-year period: a population-based study. A large proportion of surgeons consider other factors such as patient age, total injury burden, and comorbidities in addition to vital signs when deciding to perform an EDT.

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Salmonella Typhimurium induces SPI-1 and SPI-2 regulated and strain dependent downregulation of MHC II expression on porcine alveolar macrophages. Long-term antithrombotic treatment with tinzaparin 175 IU/kg/day, a low-molecular weight heparin (LMWH), could be reliable and well tolerated, although an indefinite special follow-up, including neurological controls, is advisable even in asymptomatic patients. A CK isoenzyme migrating between CK-MB and CK-BB was detected in the serum of three patients with metastatic prostatic carcinoma. Complex biochemical mechanisms are being involved in oleaginous microorganisms during storage lipid and polysaccharide metabolism. This study investigated in situ the effect of iron (Fe) on the reduction of demineralization of bovine enamel, as well as on the composition of dental biofilm.

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Peculiarities of histamine metabolism in chronic hepatitis and liver cirrhosis These were evaluated microscopically, without using analgesia or an antibiotic during the postoperative period.

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Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. Validation of a Modified Child-Turcotte-Pugh Classification System Utilizing Insulin-Like Growth Factor-1 for Patients with Hepatocellular Carcinoma in an HBV Endemic Area. Frailty is a common and important geriatric syndrome, distinct from any single chronic disease, and an independent predictor of mortality.

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Cystic lymphangioma of the spleen associated with intramural gastric pancreas Ecchymosis of the penis at the site of injection was common and 1 patient experienced priapism that resolved spontaneously.

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The BP measurements were obtained independently between the two methods. After adjustment, children reared in a family experiencing high levels of adverse life events are more likely to experience a lifetime ever DSM-IV diagnosis of depression, are more likely to have experienced multiple episodes of lifetime ever depression, and are more likely to report their first episode of depression was at a younger age. The SEM studies showed a subtle difference in the surface morphologies of formulation particles after lyophilization.

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The pupil light reflex measurement is part of the routine monitoring for severely head-injured patients. The promoter up phenotype is concluded to be due to a change in the primary structure of the -35 element with the consequent production of a better cluster of hydrogen bond donors and acceptors for the RNA polymerase. We examined the fluorescence of these polyps and compare with previously reported data.

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A series of sertraline analogues 4-39 which possess polar groups on the fused tetrahydronaphthalene ring, targeting reduced V(d) as a strategy to reduce T(max) and increase rate of elevation of central 5-HT levels, were prepared. Intestinal microbiota is a plastic factor responding to environmental changes. The efficacy and safety of diagnostic laparoscopy and ultrasonography, lowering the rate of useless laparotomies, is evident in most studies.

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As a highly vascularized organ, the ovarian structures and functions change in response to external stimuli that include but are not limited to pituitary gonadotropins. This paper confirms earlier work that medication-related harms are common, occur both in hospitals and in the community, and are a substantial burden for patients and our healthcare system.

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WHtR is a simple and convenient method of effectively identifying obese children who are candidates for hepatic steatosis screening. The beta-catenin membranous expression decreased between cholecystitis and malignant tissue, as well as between normal epithelium and carcinoma. To investigate if a comprehensive liquid biopsy-based AR profile may improve patient stratification in the context of second-line endocrine therapy.

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In the target stimulus with masking stimulus conditions with the 48- and 144-ms masking stimulus, the root mean square value did not differ from that in the respective Single-condition, while the root mean square value for the target stimulus with masking stimulus conditions with the 16-ms masking stimulus was significantly smaller than that in the Single-condition with the 32-ms masking stimulus, but not different from that in the Single-condition with the 16-ms masking stimulus. The synthesized materials can be regenerated after washing with water and reused for sensing of amines. Prenatal maternal stress has been related to neonatal activity and irritability in both lower animals and humans in documented research for at least the past 30 years.

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Influence of porto-caval anastomosis on the activity of cytoplasmic, mitochondrial and microsomal enzymes in the rat liver Of the 134 couples who participated, 109 achieved a first live birth with ART. Abstracts of the XIV International HIV Drug Resistance Workshop: Basic Principles and Clinical Implications. The correlation between fasting plasma insulin and HDL cholesterol remained statistically significant in non-insulin-dependent diabetic subjects and in female non-diabetic control subjects after adjustment for body mass index, alcohol intake, physical activity, smoking, and fasting plasma glucose.

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The cocrystal explosive has better detonation performance than HMX. It is effected by functional NK cells which express inhibitory killer cell immunoglobulin-like receptor(s) (KIRs) for self-class I ligand(s), sense missing expression of donor KIR ligand(s) in the recipient, and mediate alloreactions. Ni(II)-Fe(II) hybrid hemoglobins, in which hemes in either the alpha or beta subunit are substituted with Ni(II) protoporphyrin IX, have been prepared and characterized. After the prestimulus dose was decreased or the calcium dose was increased, however, the pancreatic secretory response to hypercalcemia was preserved.

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The comprehensive hygienic assessment of working environment for main occupational groups Railway Car Repair Plant in factory conditions shows that workers are exposed to the impact of factors of chemical nature in concentrations exceeding maximum allowable (lead, manganese, alkali caustic, sulphuric and nitric acids, chromium trioxide, silicon-containing dust, white corundum, diiron trioxide, silicate-organic dust, wood and carbon dusts), the high level of noise, the local vibration, insufficient levels of artificial lighting. The plexus is an arteriovenous anastomosis functioning without intermediary capillary bed, we report a case of glomus tumor affecting the nailbed of left little finger with characteristic periodic, spontaneous excruciating pain and temperature related algesia for the last 6 months. Rootlet morphology shows that the Oomycetes excluding the Thraustochytriales, the Thraustochytriales independently, and the Hyphochytriomycetes probably evolved as three distinctive lines from chrysophycean ancestors.

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Locomotory patterns and external morphology of the river otter, sea otter, and harp seal (Mammalia). 333 patients were randomly selected from an inception cohort of 1192 patients with BAV identified between 1986 and 1999. Visual experience is essential for the establishment of the cerebral cortical circuitry that allows normal binocular vision. Plasma LH levels after ovariectomy, corpus luteum removal and estradiol administration in cattle.

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The results showed positive effects of controlled passive motion on tendon repair. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). Anopheles mosquitoes are hypothesized to locate, discriminate among, and select such sites using olfactory cues, and that synthetic volatile blends can mimic these olfactory-guided behaviours. A comparative radiographic investigation of femoroacetabular impingement in young patients with and without hip pain. This assay was applied effectively to an insulin secreting cell line, INS-1E cells, as well as pancreatic islets, allowing us to validate the assay by elucidating mechanisms by which dopamine regulates insulin release.

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The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels. Cancer cells are characterized by epigenetic dysregulation, including global genome hypomethylation, regional hypo- and hypermethylation, altered histone modifications, and disturbed genomic imprinting. The proposed procedure is applicable in many other proteomic studies involving CE-MS of peptides. Endoscopic approaches are the alternative options in the treatment of upper gastroenterology variceal hemorrhage in hemodialysis-dependent patients without severe complications.

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The suppressive effect of platelets on megakaryocyte colony formation reached a plateau at normal human blood platelet concentration and was specific for CFU-M growth, since marrow cell erythroid burst formation (BFU-E) and granulocytic-monocytic colony formation (CFU-GM) remained unaffected. Through the on-site audit program, we could effectively detect an inappropriately operating linacs and provide some recommendations. New materials and methods are needed to better control the binding vs. Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease. Model-based studies of responses of auditory nerve fibers to electrical stimulation can provide insight into the functioning of cochlear implants.

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The major conclusion is that basics of disaster management should be included in pediatric training. Engaging communities in education and research: PBRNs, AHEC, and CTSA.

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On the structure of the rudimentary sense cell of the pineal body of the chicken Sprague-Dawley rats, injected in the hind paw with heat-killed mycobacteria dispersed in oil, develop a severe polyarthritis. In phase 2, we implemented a multidimensional infection control approach that included outcome surveillance, process surveillance, feedback on CAUTI rates, feedback on performance, education, and a bundle of preventive measures.

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Evaluation of a Novel Intervention to Reduce Unnecessary Urine Cultures in Intensive Care Units at a Tertiary Care Hospital in Maryland, 2011-2014. Report from Congress of the Baltic Medico-Legal Association (BMLA), Department of Forensic Medical Examination, Russia, Saint Petersburg, 6-9 October, 2004 Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patients. These results suggest that gGlu-HMRG can improve endoscopic detection of CAC with a higher target to background ratio than conventional white light colonoscopy.

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The aim of the current narrative review is to appraise the role of epigenetics in CKD, and highlight the potential future therapeutic pathways. In preparations without endothelium, histamine at low concentrations (1-100 nM) produced only a small and rapid vasodilation, whereas histamine at concentrations higher than 1 muM produced triphasic vascular responses: initial sharp vasodilation followed by transient vasoconstriction and subsequent gradual vasodilation.

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Specificity and mechanism of action of bovine placental adenosine deaminase. Non-invasive brain stimulation for dystonia: therapeutic implications. Individuals infected with human immunodeficiency virus (HIV) are at elevated risk for depressive conditions, which in turn can negatively impact health-related behaviours and the course of illness. This simulation has been used to study the effect on scanner deadtime and pulse pileup at high activity levels due to the scintillator stopping power (mu), decay time (tau) and energy resolution.

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RNAi knockdown of both xMiRP2 and xMinK eliminates the correlation between Kv2.1 expression level and activation kinetics. Despite decreased blood volume secondary to dehydration, and decreased systolic BP, the 6-OHDA group failed to show the expected increase in serum VP. Only half the patients treated by surgery were well enough to return home, although less severely ill patients treated by medical methods or conservatively were all able to return home. iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage induced by reducing dietary loading. A current study about maternal postures and fetal position is in progress.

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Several general reactions used for the preparation of ion-exchange membranes were described. Plasma concentrations of cortisol and 5-hydroxytryptamine significantly increased following exposure to heat. The study showed that CAPPs demonstrate strong bactericidal and fungicidal properties in vitro. These include voice recognition software, pre-sign-out quality assurance, image utilization, and computerized provider order entry. Semi-permeable membrane devices (SPMDs) were deployed at each wetland outflow to determine exiting pesticide load.

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How might health services capture patient-reported safety concerns in a hospital setting? We demonstrate the method on TIPS-pentacene in 3-methylpentane at 77 K. Domestic Violence and Abuse (DVA) is associated with a range of psychosocial and mental health problems. The diagnostic performances of noninvasive fibrosis tests were evaluated using the area under the receiver operating characteristic curve (AUROC). In this regard, local strategies for the control of MCF should consider separating reservoir species from susceptible animals.

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Problems of industrial hygiene and health conditions of workers employed in the production of latex polyvinylchloride To extend our previous research by determining whether, and how, the impact of managed care (MC) on substance abuse treatment (SAT) services differs by facility ownership. Para-aortic lymph node involvement in women with endometrial carcinoma (EC) is a poor prognostic factor. Effector functions of endothelium in inflammatory and immunologic reactions.

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The study was conducted in the emergency department of the Baruch Padeh Medical Centre, Poriya, Israel. Contact co-culture was achieved for morphological observation using red fluorescent protein (RFP)-labelled chondrocytes and green fluorescent protein (GFP)-labelled osteoblasts, and non-contact co-culture achieved by transwell chambers. The three proteins do not bind to other anionic lipids, including gangliosides, phospholipids, or cholesterol 3-sulfate. In multi-component bilayers, however, the incidence of protrusion events does not clearly depend on the mismatch between tail length or tail saturation of the constituent lipids.

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These blood cells were identified in inflamed spinal cord and in the brain in chronic active lesions of multiple sclerosis and in the related animal models referred as Experimental Autoimmune Encephalomyelitis. The diagnosis of chronic rhinosinusitis was based on the definition in the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2012. In vitro-in vivo correlations using real-time and accelerated release data have been developed, to minimize the need to conduct in vivo performance evaluation.

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Sensing mechanisms and strategies of Au NP based optical systems are provided to show basic concepts in designing sensitive and selective sensing systems. Plasma levels of cyclophosphamide and its two cytotoxic metabolites, 4-hydroxycyclophosphamide and phosphoramide mustard, were determined in seven cancer patients randomly assigned to treatment initially with either orally or i.v.

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Effects of exogenous recombinant human basic fibroblast growth factor on the healing of muscles in rats after deep tissue injury of pressure ulcers Studies on the conformational isomers of deoxycytidylate aminohydrolase. EBUS elastography is a promising diagnostic modality for the differentiation of benign and malignant LNs during EBUS-guided transbronchial needle aspiration (TBNA). Determination of the contents of fourteen elements in urine of Xinjiang kuitun fluorine poisoning and arsenic-fluoride poisoning patients by ICP-AES The two antigen ELISAs could capture circulating or excreted antigens during clavam 375 tablet use for kids the acute phase of invasive aspergillosis (IA) in the animal model, and had no cross-reactivity to other Aspergillus-challenged animal models.

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The beauty of the alcohol-dependence syndrome construct is its apparent specificity and its potential clinical usefulness. The excitability modifications induced by a conditioning stimulus were studied in the three groups of fibers coursing in the dorsal hippocampal commissure of the guinea pig. The cumbersome logistics inherent in this technique within the clinical setting limits its practical application. Variations in the solid state form of a pharmaceutical solid have profound impact on the product quality and clinical performance. Atypical screen for lisovyr acyclovir dosing culture negative endocarditis revealed a strongly positive IgG-antibody titre against Bartonella henselae.

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RNA-protein interactions in the 80-S rat liver ribosomes were studied by measuring cross-linking of proteins to rRNAs induced by ultraviolet radiation, as already reported for free 40-S and 60-S subunits. C18-modified silica gels with surface coverages of 2 to 8.2 micromol m(-2), were prepared by different synthetic pathways and characterized by Fourier Transform infrared spectroscopy (FTIR), solid-state nuclear levofloxacin dosing in peritoneal dialysis magnetic resonance (NMR) spectroscopy, and chromatographic measurements. Rheumatoid arthritis can lead to induction of Th17 cells, which express IL-17. The aim of this study was to examine the association of all-cause and diagnosis-specific sickness absence with subsequent changes in physical and mental health functioning among ageing municipal employees.

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Endoscopic gastric biopsies recorded in the surgical pathology register of the department from 2005-2009 were studied and relevant demographic and clinical information extracted from the registers, original request cards and patient case files. The following variables were noted: pelvic incidence and version, sacral slope, lumbar lordosis, thoracic kyphosis, T9 sagittal tilt and S1-S2 angle. In this study, we selected four single nucleotide polymorphisms (SNPs) in different CLRs to determine whether there could be a role for these CLRs in IBD. We retrospectively compared 2 groups of hips that underwent total hip arthroplasty using a metaphyseal filling stem (78 hips) or a tapered wedge stem detensiel 10 mg indication definition (83 hips). Importantly, the effects of TAPI-0 on bleomycin-induced inflammation and apoptosis were reversed by coadministration of specific Mer-neutralizing antibodies.

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