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Anticol (Disulfiram)

Anticol is an orally bioavailable carbamoyl derivative and a proteasome inhibitor that is used in the treatment of alcoholism, with potential antineoplastic and chemosensitizing activities. Anticol (DSF) may help to treat alcoholism by irreversibly binding to and inhibiting acetaldehyde dehydrogenase, an enzyme that oxidizes the ethanol metabolite acetaldehyde into acetic acid. Inhibition of acetaldehyde dehydrogenase leads to an accumulation of acetaldehyde and produces a variety of very unpleasant symptoms, which together are referred to as the Anticol-ethanol reaction (DER). In addition, DSF has a strong ability to chelate metals and its antineoplastic activity is highly dependent upon binding to copper (Cu), a metal that selectively accumulates in cancer cells. DSF/Cu generates reactive oxygen species (ROS) and inhibits proteasome activity, leading to an accumulation of ubiquitinated proteins; both of these processes result in induction of apoptosis. Also, DSF/Cu inhibits various cancer-specific pathways, which leads to inhibition of tumor cell growth.

Other names for this medication:
Disulfiram, Antabuse, Anticol, Aversan, Esperal, Etabus, Tenutex,

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Anticol is used to help overcome your drinking problem. It is not a cure for alcoholism, but rather will discourage you from drinking.

Anticol is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

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Elevated preoperative neutrophil-to-lymphocytes ratio predicts poor prognosis after esophagectomy in T1 esophageal cancer. In the clinical anterior instability cohort, we demonstrated a statistically significant higher number of HS and glenoid chondral lesions than in controls. Decidualized stromal cells of pregnancy differ in this respect from stromal cells obtained from nonpregnant uteri, which are not associated with any significant amounts of basement-membrane components. Collectively, this work is intended to inspire establishing comprehensive and standardized guidelines for multi-site studies. Thus, the aim of this study was to investigate whether the decreased oocyte competence of RB cows (RBs) during summer is associated with an altered gene expression profile and a decrease in mitochondrial DNA (mtDNA) copy number.

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Many epidemiological studies have evaluated the effects of maternal air pollutant exposure on fetal growth. In pancreatic cancer, the presence of obesity or weight loss is associated with higher mortality.

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Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer. Therefore, numbers are processed using both a generalized magnitude system and format specific number regions. Postpartum sterilisation with the Filshie titanium silicone-rubber clip and subsequent pregnancy. Blood Pressure Treatment Targets in Adults Aged 60 Years or Older.

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With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. Erratum to: South African Herbal Extracts as Potential Chemopreventive Agents: Screening for Anticancer Splicing Activity. Furthermore, a novel approach has been proposed to realize the real-time monitoring of biotin-STA binding affinities and kinetics by analyzing the PEC sensing characteristics.

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Impact of mental disorders upon elderly American Indians as reflected in visits to ambulatory care facilities. For the extensive cytoplasmic tails of eukaryotic CLC family members, however, there are no equivalent structural predictions. Spinal cord stimulation for complex regional pain syndrome: a systematic review of the clinical and cost-effectiveness literature and assessment of prognostic factors. Further, unlabeled Nrf2 peptide containing the Kelch-binding motif was added to the (15)N-labeled Kelch sample.

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A prospective study included patients in whom NSCLC was diagnosed at an Australian cancer hospital between 2012 and 2014. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, its ectopic overexpression in plants would be expected to give outcomes distinct from those observed from overexpression of animal SNAT genes in transgenic plants. Leaflet washes containing trichome secretions from each of three hybrids, including the two having repellent leaflets, were repellent in bridge bioassays.

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Relative to EBRT techniques, brachytherapy techniques have a lower integral dose and more rapid fall-off, allowing for high-dose delivery with little normal tissue exposure. Debridement of the fibrous ankylosis and transplantation of the bone graft into an anterior tibiotalar groove. We show how nonparametric statistical methods can be used to redress this situation, and we discuss how the knowledge of the statistical error can be used to speed up the characterization efforts for future x-ray observatories. Plasma insulin levels were unchanged by the operation, either fasting or following the stimulus of an oral glucose load or intravenous tolbutamide. Quadriphasic waveforms are superior to triphasic waveforms for transthoracic defibrillation in a cardiac arrest swine model with high impedance.

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Quantitative measurement of the material properties (eg, stiffness) of biological tissues is poised to become a powerful diagnostic tool. Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report. A comprehensive database management system for a variety of clinical trials. Successful endodontic diagnostics and therapy call for adequate depiction of the root canal anatomy with multimodal diagnostic imaging.

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Incidental parathyroidectomy during thyroid surgery: an underappreciated complication of thyroidectomy. hyodysenteriae contained more mucus, and fecal smears contained more T. Atraumatic restorative treatment and minimal intervention dentistry.

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To establish normal cerebral blood flow volume by measuring flow volume of the extracranial carotid and vertebral arteries using Doppler ultrasonography in healthy adults. All the B-cell clonality assays, including IgH-FR2, IgH-FR3, DH-JH, Igkappa, and Iglambda PCR, showed a polyclonal pattern. Parametric uncertainty in nanoscale optical dimensional measurements. Preliminary research on the use of 2 laboratory tests as indices for lead absorption in a petroleum refinery

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These data indicate that the process by which supercoiled plasmids are made can influence plasmid stability and biological activity and emphasize the need for more rigorous methods to evaluate supercoiled plasmids as gene-delivery vehicles. The oxygen equilibrium properties indicated that modified Ni-Fe hybrid hemoglobins remain good models for the corresponding deoxy ferrous hemoglobins, although K1, the dissociation equilibrium constant for the first oxygen to bind to hemoglobin, was decreased by the chemical modifications.

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Experiments show that EK-ESI can reduce charge competition effects in the ESI source and increase biomolecule detection sensitivities. A triage approach for the diagnosis and immediate treatment of thoracic trauma is presented.

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Multiple leakage of lysosomal enzymes from cystic fibrosis fibroblasts into the extracellular space has been suggested to occur but was not observed in these experiments. Unzipping analysis with mismatch substrates containing an end blocked by lac repressor allowed us to identify MSH proteins present on DNA between the mismatch and the block, presumably in an ATP-dependent sliding clamp mode.

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Nutrition and lifestyle in healthy aging: the telomerase challenge. The in vitro aged collagen was less susceptible to pepsin than the untreated collagen.

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Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma. Here we describe detailed methodologies for both traditional and novel assays utilised for the detection, quantitation, and functional characterisation of alloreactive T cells and highlight the key advantages and disadvantages of each system.

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Despite the requirement of LG1 for 4C7 binding, a recombinant LG1 module failed to bind to 4C7 when expressed alone or in tandem with LG2, but exhibited significant 4C7 binding activity when expressed as an array of LG1-3. In this study we describe a female patient with dysmorphic features, hepatomegaly, thick myocardium and psychomotor delay.

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Prognostic characteristics of cardiopulmonary exercise testing in heart failure: comparing American and European models. The spared nerve injury (SNI) model is a new animal model that can mimic several characteristics of clinical neuropathic pain. During immersion suppression of plasma noradrenaline and adrenaline was observed but no change occurred in plasma dopamine levels. The average preoperative knee function score increased from 41.4 points (range, 20-60 points) to 75.8 points (range, 45-95 points).

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Is sonography superior to enzyme diagnosis in the detection of hepatic steatosis? Full-face Er:YAG laser therapy was performed in a 30-year-old female patient with a 15-year history of cosmetically bothersome facial EVHCs. Results of an experimental school-based health development programme in Australia. A 3-day cell phone training session with low- and nonliterate traditional midwives in rural Liberia improved their ability to use mobile technology for SMS texting. PID, but not D6PK, can also induce PIN1 polarity shifts, seemingly through phosphorylation at S1-S3.

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Microbe Profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans. The nanodiamonds studied in these experiments were as-received (ND), purified and carboxyl terminated (ND-COOH), and aminated (ND-NH2). Trinitrobenzenesulfonic acid: a possible chemical probe to investigate lipid-protein interactions in biological membranes. Due to uneven demand for wood fuel, the material is mostly stored outdoors in chip piles or as logs until utilisation. The effects of an antiserum to the contractile proteins of the heart on the developing rat embryo.

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Eight patients with hemangioma with functional impairment, cosmetic disfigurement, or rapid growth were treated with propranolol. Trained interviewers administered the pretested survey instrument in Spanish or English. The UTP site could not be distinguished from that for the nucleotide sugar.

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The combination is well tolerated at the recommended phase II oblimersen sodium dose of 7 mg/kg/day CIVI days 1-8 with irinotecan 280 mg/m2 intravenously on day 6 every 3 weeks. Effect of onion on electrophoretic pattern of serum proteins in alimentary lipemia. When part of the repeat was deleted, it lost its ability to bind as well as influence copy number.

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Biosynthesis of amino acids from various species of yeasts cultivated under definite conditions Cw6 allele is the most extensively investigated candidate gene, but present evidence suggests that it is rather in strong linkage disequilibrium with the PSORS 1 gene than the susceptibility allele itself. Conversion from cyclosporine to bredinin in canine orthotopic liver transplantation.

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Photo-oxidation effects on beta-hydroxybutyrate dehydrogenase: studies of membrane fragments and intact mitochondria. Thus, we demonstrate that while production of ROS is involved in L. Further, the most important factors in determining transmission suitability are precipitation of the wettest quarter, annual precipitation, mean temperature of the coldest quarter and mean diurnal range. The reasons for this success are discussed in light of anatomic studies. An update on polysaccharide-based nanomaterials for antimicrobial applications.

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The revised trauma score (RTS) was calculated for each patient at presentation and at 12, 24 and 48 hours subsequently. Several studies have highlighted the relevance of microRNAs in adipocyte differentiation, but the contributions of long non-coding RNAs (lncRNAs) are still largely uncharacterized.

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Knock-out (KO) mouse models have been increasingly used to dissect the roles of genes in development, diseases, and injuries. Ultrasound elasticity imaging has been developed over the last decade to estimate tissue stiffness. Overall, the present study sets the basis for potential emotional mechanisms that could explain how cultural symbols can act as extensions of the prototypical attachment figures and confer the sense of security in the face of threat. Findings indicate hit reports rarely contribute to identification, arrest, charging, or sentencing of suspects, because of delays in producing hit reports.

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Similar cases reported in the literature are reviewed, with a discussion of clinical management, implications of permissive hypercapnia and neurological complications in ventilating asthmatic patients and the importance of safe drug handling by staff members. Taste of home: lawmakers are balancing strict food safety laws with policies to encourage small food entrepreneurs. The most known uses of cork are in stoppers (natural and agglomerated cork) for alcoholic beverages, classic floor covering with composite cork tiles (made by the binding of cork particles with different binders), and thermal/acoustic/vibration insulation with expanded corkboard in buildings and some other industrial fields. Motor cortex stimulation in refractory pelvic and perineal pain: report of two successful cases.

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Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion. We aimed to evaluate the ability of CIMT to further risk stratify patients. Due to deterioration of vertigo, hearing loss and tinnitus in the right ear the patient was referred to the additional neuroradiological examination which confirmed the diagnosis of spontaneous intracranial hypotension syndrome. Partial relaxation of the left cupula of the diaphragm simulating a tumor of the mediastinum

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The purpose of this study was to investigate the factor analytic structure of the Willoughby Schedule in an inpatient psychiatric population. It was observed that there was some disagreement in clinical and histopathological classification. Chitosan-Coated Collagen Membranes Promote Chondrocyte Adhesion, Growth, and Interleukin-6 Secretion.

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Resuscitation of patients with high risk of hemorrhage and thromboembolism. TAAR1 activation by a selective small molecule agonist increased glucose-dependent insulin secretion in INS1E cells and human islets and elevated plasma PYY and GLP-1 levels in mice. These proteins, called alpha-agglutinin, were labeled with 125I-Bolton-Hunter reagent. The overall results suggested (although cadaver transplant outcome did not confirm) a lower incidence of rejection on the twice-daily compared with the once-daily regimen. Short-term studies have shown that somatostatin analogues are effective in patients with polycystic kidney and liver disease.

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In this computational study, we present molecular dynamics simulations of water/aerosol-OT/isooctane reverse micelles with different water loading. Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment.

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Gastrointestinal (GI) cancer, including gastric cancer (GC), colorectal cancer (CRC), and esophageal squamous cell carcinoma (ESCC), is the most common malignancy worldwide. Additionally, the enkephalin-hydrolyzing aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A in rat vas deferens were found to be inhibited maximally with 1 microM of amastatin, 1 microM of phosphoramidon and 1 microM of captopril, respectively. The patients received gemcitabine intravenously over 30 min on days 1 and 8 and S-1 orally twice daily from days 1 to 14. Cerebral oxygenation and other physiological measurements in ventilated preterm infants did not differ between SSC and incubator care. The role of adipose tissue in pathogenesis of type 2 diabetes mellitus

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Golgi impregnations and fluorescent tracer injections revealed that the calyces are exclusively supplied by visual neurons from the medulla of the dorsal eye optic lobes. It is possible to represent the age dependent change of the ability of reproduction on the model of liver regeneration. All synthesized pyrazoline derivatives showed moderate antimicrobial activities against bacterial and fungal strains.

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The diagnosis was made by pneumoencephalography (two patients), by CT scan (one patient) or by both techniques ((one patient). Following administration of 600 mg of indoprofen per day for 7 days, no changes are observed in the drug plasma level profile. Acquisition and Presentation of Tumor Antigens by Dendritic Cells. Predicting sarcopenia from functional measures among community-dwelling older adults.

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It is important to understand the physicochemical mechanisms that are responsible for the morphological changes in the cell membrane in the presence of various stimuli such as osmotic pressure. HO-1 induction in the guinea-pig stomach: protection of smooth muscle functional performance during cobalt-induced oxidative stress.

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A 39-year-old woman with CF presented with nausea, severe abdominal pain, and obstipation. Our objectives were twofold: to evaluate the incidence and time to recovery of premorbid function within 6 months of a critical illness and to identify independent predictors of functional recovery among older ICU survivors. The exposure needed to remove the previously implanted plate may be extensive. Finally, using the dataset with missing annotations, predictive models can be derived in cases where no accurate dense dataset is available (not enough data overlap or no well balanced class distribution).Graphical abstract. ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp.

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Viruses from humans were generally more pathogenic in mice and ferrets than those from birds. Chemical factors in the formation of steady states in the central nervous system. Analysis of the results of a national pharmacovigilance study on Implanon, a contraceptive implant containing 68 mg of etonogestrel. Toll-like receptor 3 (TLR3) plays an important role in antiviral responses through recognizing viral double-stranded RNA produced during viral infection and mediating induction of type I IFN. The results indicated that the reactions of PZ species having NH group with N2O3 contribute the most to the formation of nitrosamines in the absorber unit of PCCC and follow a novel three-step nitrosation mechanism, which is initiated by the formation of a charge-transfer complex.

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We drafted all the main evolutionary steps that led to the current structure and gene content of Pseudoalteromonas representatives. The aim of this review article is to highlight currently available options for minimization of complications and standardization of deep anterior lamellar keratoplasty (DALK) for keratoconus. Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397). Enrichment of Mammary Basal and Luminal Cells for Cell-of-Origin Metastasis Studies.

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The crystal structure of a specific complex between the DNA-binding domain of phage 434 repressor and a synthetic 434 operator DNA shows interactions that determine sequence-dependent affinity. Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: arcolane shampoo uses An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial.

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Peripheral Atheromatous Arterial Disease in the Young: Risk Factors, Clinical Features, and Prognosis From sumatriptan mechanism of action in migraine treatment the COPART Cohort. Influenza viral antigen was demonstrated in areas closely associated with histopathologic lesions. Impact of Collaborative Care for Underserved Patients with PTSD in Primary Care: a Randomized Controlled Trial.

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History of exposure to TB and past treatment information should be taken into consideration for proper interpretation of the antibody test results. Effects of some vasoactive drugs on the calton violin case for sale vessels of cerebral grey matter in the dog. Modified roller drum apparatus for analyzing effects of pollutant gases on tissue culture systems. Numerous biological functions are related to protein glycosylation. Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome.

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An extremely rapid burst of respiration upon aeration of mitochondria: measurement of oxygen tension with 10-msec time resolution. Electron microscopic study of the synchronized stages confirmed the observations of Sinden (1982) but, in addition, we noted the presence of Garnham bodies, a cytostome in all stages and dense spherules in stages I-III similar to the fenestrated buttons in sporozoites and exoerythrocytic forms. RNA interference (RNAi) was used to knock down the GPR3 expression within oocytes. IL-25 derived prinivil 20 mg picture from epithelial cells has the potential to promote airway remodeling in asthma

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Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol diclofenac ratiopharm 75 mg sl retardkapseln alkoholilaskuri during early postnatal period. Parietography in the roentgen-diagnosis of cancer of the upper section of the stomach A high-resolution survey of deletion polymorphism in the human genome.

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A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. Mouse models also provide an experimental paradigm to gain a mechanistic understanding of the environmental factors that influence NTD occurrence, such as folic acid and maternal diabetes, and have led to the discovery of additional preventative nutritional supplements such as inositol. An alternative gallbladder extraction technique in images of losartan potassium 100 mg laparoscopic cholecystectomy.

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Nonacarbonyldivanadium: parkizol 5 mg alternatives to metal-metal quadruple bonding. Improved anticoagulant effect of fucosylated chondroitin sulfate orally administered as gastro-resistant tablets. Minimizing eddy currents induced in the ground plane of a large phased-array ultrasound applicator for echo-planar imaging-based MR thermometry.

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Computer-assisted navigation systems are now able to assist difficult surgical procedures in the field of otolaryngology. The on-demand nature of this food application requires rapid color outputs which could be provided by the color matching technique, currently used in nonfood industries, rather than by empirical food industry methods. losec tablets omeprazole magnesium vs omeprazole Generalization tests were conducted after 20-min inhalation exposures to toluene (150-3600 ppm) and 20 min after injections with either PB (5-30 mg/kg) or morphine (3-20 mg/kg). General practitioners in regional and rural areas may be required to interpret emergency imaging of their patients without the immediate assistance of a radiologist.

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Comparison of microbiological activities of the phyllosphere and rhizosphere of some agricultural crops at the pre-flowering stage. Effectiveness of Liquid-Liquid Extraction, Solid Phase Extraction, and Headspace Technique for Determination of Some Volatile Water-Soluble Compounds of Rose Aromatic Water. Moreover, dietary additives such as activated charcoal, phenobarbital, baktar shikan vs nag cysteine, glutathione, betacarotene, fisetin and selenium have also been reported to be effective in the reduction of aflatoxicosis in poultry.