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Genotoxic and mutagenic effects were especially found for the Gemfibrozil photoproduct suggesting that also byproducts have to be considered in the environmental risk of drugs. The end-point rate, consisting of fatal and non-fatal myocardial infarction and cardiac death, did not differ significantly between the placebo and Gemfibrozil groups.

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Gemfibrozil, Lopid,

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Gemfibrozil is used along with a proper diet to help lower fats (triglycerides) and raise "good" cholesterol (HDL) in the blood. It may also help to lower "bad" cholesterol (LDL). Gemfibrozil belongs to a group of drugs known as "fibrates. " It works by decreasing the amount of fat produced by the liver. Lowering triglycerides in people with very high triglyceride blood levels may also decrease the risk of pancreas disease (pancreatitis). However, gemfibrozil might not lower your risk of a heart attack or stroke. Talk to your doctor about the risk and benefits of gemfibrozil. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, drinking less alcohol, losing weight if overweight, and stopping smoking.

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Our results are congruent with a resource-consumer competition model, which predicts that cooperative, virulent agrobacteria are at a competitive disadvantage when opines are unavailable, but have an advantage when opines are available at sufficient levels. Influence of repeated lepromin injections on the Mitsuda skin reaction. Comprehensive analysis of aberrantly expressed microRNA profiles reveals potential biomarkers of human lung adenocarcinoma progression. However, traditional FT for the comparison of multiple learning algorithms on different datasets adopts the naive ranking approach. Ectopic ureteral anastomosis and urethro-vulvo-perineal abnormalities (a case in a young girl)

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Pyramidarrays composed of 1000 nm pit size with 1250 nm pitch lengthwerereplicated on a plastic substrate by roll-to-roll (R2R) ultraviolet (UV) embossing. The review of current literature identified a critical gap in the study of environments: There is the need to study exposures at community and societal levels. No HR patient responded to thalidomide and all died of pulmonary, liver, or bone marrow failure.

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CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Future studies on the HE4 renal secretion and HE4 degradation dynamics in urine are also required for the establishment of standard protocols for the application of urine HE4-test in clinical settings. Role of serine proteases of Schistosoma mansoni in the regulation of IgE synthesis. Interestingly, ERBB2 silencing has a similar impact to miR-133a overexpression, in that it significantly induced apoptosis and inhibited ERK and AKT activation.

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The phase diagram obtained in this work, which is found to be consistent with previous simulation studies, is close to its experimental counterpart provided the TIP4P/Ice model is used to describe the water molecule. Progression of impairment in adolescents with attention-deficit/hyperactivity disorder through the transition out of high school: Contributions of parent involvement and college attendance. Size and structure matter: enhanced CO2 photoreduction efficiency by size-resolved ultrafine Pt nanoparticles on TiO2 single crystals. Associative and familiarity-based effects of environmental context on memory.

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Recently, due to spread of dangerous and especially dangerous infections much attention is given to development of complex approaches to their prophylaxis and therapy. We investigated the clinical and prognostic impact of variant histologies on upper tract urothelial carcinoma outcomes after radical nephroureterectomy. We undertook this trial to determine if a cytoprotective dose of arbaprostil (10 micrograms q.i.d. Pulmonary diffusing capacity and physical working capacity in swimmers and non-swimmers during growth. Recurrent inflammation and vasculopathy occur in sickle cell disease.

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The intention was to investigate whether AD could be used for waste disposal (either alone, or in combination with another process) such that both energy can be obtained and potentially hazardous materials be disposed of. Iron enters BM-MSCs through both transferrin-dependent and transferrin-independent mechanisms, inducing the accumulation of cyclins E and A, the decrease of p27(Kip1), and the activation of MAPK pathway. Patterns of Social Affiliations and Healthcare Engagement Among Young, Black, Men Who Have Sex With Men.

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Analyses indicate patient responses to similar HBQ-P questions have sufficient reliability to support the use of the Health Background Questionnaire for clinically related data collection and for outcome evaluation of treatments for chronic and recurring pain. In the females, congestion of the alveolar capillaries (at 500 mg/kg) and liver bridging necrosis (at 200 mg/kg) were significantly increased. Elevated Urinary T Helper 1 Chemokine Levels in Newly Diagnosed Hypertensive Obese Children. Female athletes may be at greater risk for disordered eating than their nonathletic peers, but the psychological antecedents of this dysfunctional behavior in athletes have yet to be elucidated. We use it as the loss function in a max-margin learning framework to find parameters of an automatic neuron segmentation algorithm.

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Cranial DAVFs with no reflux flow and those with reflux flow drainage into the sinus only, the bridge vein only, the bridge vein and pial vein, and the sinus, bridge vein, and pial vein were designated as types 1, 2, 3, 4, and 5, respectively. Neither actigraphy nor subjective estimates are suitable for estimating sleep efficiency and latency.

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Loss of mitochondrial membrane potential was analyzed by flow cytometry using rhodamine 123 staining. The sexual abuse of children: a widespread problem receives close attention. Our approach was to investigate whether intraarterial application of 131I-MIBG has the potential to enhance tumor uptake.

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We analyzed the promoter hypermethylation of DUSP2 in human cancer, including primary Merkel cell carcinoma by bisulfite restriction analysis and pyrosequencing. Patients with osteoporosis had impaired postural control when assessed with computerized instruments.

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To evaluate the care and outcomes for patients presenting with floor of mouth (FOM) cancers. signification by quoting it in comparison to the dynamic tests of erection (artificial erection, papaverine test, nocturnal penile tumescence (N.P.T.) with the findings of arteriography. Method of continuous determination of ionic composition (pH,pNa,pC1) in the wall of small intestine in animal experiments

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The effect of new local anaesthetics on tracheal and anococcygeal smooth muscle. The findings of this study could provide valuable information for the understanding of mechanisms underlying miR-dependent vascular calcification as well as potential treatment target for the disease. Severe erythema and pustules after antibiotic use: acute generalised exanthematous pustulosis Management of a deeply impacted mandibular third molar and associated large dentigerous cyst to avoid nerve injury and improve periodontal healing: case report.

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All 4 IMRT techniques allowed FFF beams to generate acceptable plans for breast IMRT. Indeed, a physiological decrease of Glo1 transcription and activity occurs not only in chronic hyperglycaemia but also with ageing, during which MGO accumulation occurs. The receptors for insulin and epidermal growth factor possess tyrosine-specific protein kinase activity which may play a role in mediating the biological actions of these two peptides.

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The major obstacle to be overcome for successful targeting of drug to colon through oral route is that drug absorption/degradation must be avoided in stomach and small intestine before the dosage form reaches colon. In tomato, race-specific resistance to Verticillium wilt is governed by the cell surface-localized immune receptor Ve1 through recognition of the effector protein Ave1 that is secreted by race 1 strains of Verticillium spp. pH 11) of the assays, the lifetime of N-nitrosotryptophan derivatives is largely prolonged and the reactivity of S-nitrosothiols with aromatic amines can be safely ignored. Inhibitory effects of fungal endophytes were tested against Pseudomonas plant pathogens.

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As a step toward determining the mechanism of cytotoxicity, we chose to identify the cell cycle phase(s) during which exposure of cultured human fibroblasts to o-LDL leads to death. The survival rate and behavioral functional recovery were evaluated for 7 days following IRI.

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This rare clinical presentation suggests that in case of a disproportionate degree of visual impairment in relation to the size of the lesion, suspicion should lead to an intrachiasmatic lesion. In a context where legislation on death registration is not applied, and where conventional autopsy is not often done, verbal autopsy (VA) provides information on mortality. This concern has prompted a continuing assessment of the risk of methylmercury toxicity among fish consumers in the United States as well as other countries.

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Results from several studies favor the pH stat strategy during neonatal cardiopulmonary bypass. Additionally, a second patient developed high-flow CSF rhinorrhea 2 years after GKRS for a prolactinoma that failed dopamine agonist therapy.

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Scott Fitzgerald: famous writer, alcoholism and probable epilepsy. The intervention applied RBS training, targeted enforcement, and corrective actions by law enforcement to a random sample of 10 identified problem bars in each community compared to 10 matched nonintervention problem bars.

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Long-term failure of ablation is related to an inability to create a durable transmural lesion or to identify all of the non-pulmonary vein arrhythmia triggers. They induce symptoms typical of a type I allergy, the most significant of which is asthma. Herein, we sought mutations in six consanguineous BS families and detected changes in either PLOD2 or FKBP10 in all cases.

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Hence, SHED appear to be a promising candidate cell type for vascular tissue engineering. Compared to diploid embryos, haploids exhibited a delay in both zygotic gene expression and cell cycle lengthening, while diploid embryos with increased N/C volume ratios showed early expression of zygotic genes and premature lengthening of cell cycles.

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Magnetic resonance imaging differential diagnosis of brainstem lesions in children. There may be genes in chromosome DNA which resist iodophor, the reason for increase of resistance to iodophor may be related with the change of chromosome DNA, but not related with pO157. Cancer cells frequently express high levels of ROS-scavenging enzymes, which confer resistance to ROS-mediated cell death.

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Bluetongue virus (BTV), a member of the Orbivirus genus in the Reoviridae family, is a non-enveloped virus that is comprised of two architecturally complex capsids. These results extend the studies of concanavalin A agglutination of embryonic cells to human tissue, and they suggest that concanavalin A may be reacting with a common antigen on the fetal cell membrane. Specific chromosome aberrations (marker chromosomes) and activated regions (rDNAs) were ubiquitous in the karyotype, suggesting that the conservation of these patterns may be advantageous for tumor progression.

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Many theoretical models of community dynamics predict that species richness (S) and total abundance (N) are regulated in their temporal fluctuations. Bone regeneration in minipigs via calcium phosphate cement scaffold delivering autologous bone marrow mesenchymal stem cells and platelet-rich plasma. Although the theoretical causes of mito-nuclear discordances are well understood, it is often extremely challenging to determine the principal underlying factor in a given study system.

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We hypothesized that increased levels of LA under conditions of oxidative stress would increased production of IL-8 by vascular smooth muscle cells because LA is the dietary precursor to arachidonic acid (AA) and its metabolites that mediate inflammation. Estimated liver volume of 24 adult patients with FHF receiving artificial liver support (ALS) was measured by using computed tomography.

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The prenatal sonographic diagnosis of this rare disorder is discussed along with the clinical and pathologic findings and outcome of all reported cases. The aim of this study was to determine the accuracy (sensitivity and specificity) of LSCI on different days after injury in the prediction of healing outcome and if the accuracy can be improved by combining an early and a late measurement. Presentation of a device of Russian construction for the suturing of small vessels The ultimate goal of DNA-based diagnosis is the determination of the causative mutation, but, in general, this is possible only for large deletions, insertions, or certain nonsense mutation that, in most diseases, involve only a few percent of affected families. Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin.

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Correction: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173. The methods for longitudinal contraction venoplasty and its efficacy are reported.

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Our data suggest that, in this model system, caspase activation may be an upstream event to tau hyperphosphorylation, although additional studies will be required to fully elucidate the cascade of events. Cytoplasts from a Chinese hamster/XP-A hybrid containing chromosome 1 of XP-A origin corrected also the defect with fast kinetics.

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Thereby this study will be relevant for the development of policy, practice, and theory concerning infant mental health. To describe an unusual case of simultaneous bilateral exudative retinal detachment and peripheral necrotizing retinitis as presenting manifestations of concurrent HIV and syphilis infection. In addition, after the IVT injections, rounded enlargements of the intercellular space that resembled canaliculi were filled with reaction product. A cell and genotoxic stress: a reaction to double strand breaks of DNA Transferrin, haptoglobin and ceruloplasmin in the maternal and fetal sera

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Semi-structured interviews were conducted with people (18 males and 26 females) referred for oral care through the Aboriginal Liaison Program of the South Australian Dental Service. This defined in vitro system allowed manipulation of the copy number of displayed PA and imposed no significant limitation on the size of the displayed antigen.

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In the paper, clinical studies in the center are introduced for increasing levels of acupuncture and moxibustion research at home. Mode conversion efficiency to Laguerre-Gaussian OAM modes using spiral phase optics.

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Advances in echocardiography will allow for more objective and precise assessments of cardiac outcomes. Measurements of lung volume are important both for assessing growth and development of lungs in health and disease, and for interpreting volume-dependent lung function parameters such as respiratory compliance, resistance, forced expiratory flows, and indices of gas-mixing efficiency. Available evidence also suggests that obesity may negatively affect basal and exercise-related antioxidant responses in the peripubertal period during pre- and early-puberty.

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Cardiac Image Reconstruction via Nonlinear Motion Correction Based on Partial Angle Reconstructed Images. Human papillomavirus-positive patients were less likely to recur and had no VSCC-related deaths. Characteristics of isolates of Pasteurella multocida obtained on consecutive or different years from the same turkey farms. This study demonstrates that DFNA9 families with the same genotype may have significantly different phenotypes.

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There are no studies probing if patients in sepsis or septic shock with lower levels of total plasmatic globulins and/or lymphocyte count have higher mortality. As for the pathogenetic mechanisms responsible for this type of hypertension, measurement of urinary catecholamines has revealed a close relationship between the two phenomena. The surrounding stem cells contribute to root growth through the production of new cells that are displaced from the meristem, elongate and differentiate into specialized root tissues. Electrophysiological and biochemical experiments suggest that acetylcholine may be a neurotransmitter of these efferent fibers. Therefore, early-life stress may have sex-specific programming effects on metabolic rates and energy expenditure in song sparrows.

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The aim of this study was to investigate the effect of KOB03 on allergic responses through the regulation of mast-cell mediated allergic inflammation. This mechanism has been demonstrated with regard to blood group specificities of certain drug reactions in the case of red cells. Questions assessed knowledge, interest, and comfort with genetic testing as well as the role of genetic counselors. Identification of a new vitamin B 12 binder (transcobalamin 3) in normal human serum.

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Not only overt sinusitis, but also occult sinusitis could be a significant comorbidity in asthmatic patients. Polo-like kinases (Plks) are essential for progression through mitosis.

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Rethinking the genetic basis and inheritance of fascioscapulohumeral muscular dystrophy. Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review. Inverse imaging problems are inherently underdetermined, and hence, it is important to employ appropriate image priors for regularization. Wildlife trafficking is a major factor contributing to the reduction of biological diversity. Innominate artery perfusionis a safe and useful technique for aortic arch surgery.

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Interestingly, in vitro release studies showed that PEG-PTMC(COOH) and PEG-PTMC(NH(2)) polymersomes had pH-responsive protein release behaviors in which significantly faster protein release was observed at endosomal pH than at physiological pH. Investigation of the hepatobiliary function using rose bengal under simple laboratory conditions

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Patterns of sleep-related medications prescribed to elderly outpatients with vilpin dosing insomnia in Taiwan. Umbilical cord blood is being increasingly used as an alternative stem cell source in the treatment of children and adults with malignant and non-malignant diseases.

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Ultrasonic energy attenuation occurs in the processes of the ultrasonic generation, conversion, transmission, and reception. The pilot led to a more refined design to pair nursing and PT students, requiring them to communicate via mobile phone regarding results of examinations, and suggestions for follow-up by the nursing students, to ensure continuity of care and a more comprehensive approach to services. Pre-emptive antiviral agents for hepatitis lamitor overdose symptoms B before chemotherapy to prevent viral reactivation and caution in using potentially hepatotoxic drugs can prevent the development of ACLF.

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We report a case of cervical spondylodiscitis, occurring in a 67-year-old woman submitted to phonatory prosthesis insertion. Interactions between nanoparticles and biological membranes are attracting increasing attention in current nanomedicine, and play a key role both for nanotoxicology and for utilizing nanomaterials in diagnostics, drug delivery, functional biomaterials, as well as combinations of these, e.g., in theranostics. With the recent development of dedicated PET scanners for small animals, such as the microPET, it is now possible to perform functional imaging in small animals such as rodents at high resolution. Clinical suspicion is aroused in patients with an underlying process such as malignancy, DIC, or a spectrum of other diseases and evidence of pulmonary and/or systemic embolization. CHW programs for HIV in Southern Africa are fragmented, poorly integrated, and risperidone increased anxiety before labor lack long-term support.

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Phylogenetic comparison of entire connexin gene families from human, mouse, and zebrafish revealed 23 zebrafish relatives of 16 mammalian connexins, and 14 connexins apparently unique to zebrafish. Mathematics competency in nursing education and practice may be addressed by an instructional variation of the traditional dimensional analysis technique typically presented in beginning chemistry courses. Local treatment of chronic osteomyelitis with surgical debridement and tigecycline-impregnated calcium duzela $20 tablet computers hydroxyapatite: an experimental study. Some peculiarities of infectious wounds and their therapy in newborn infants The Who, What, and How of Cabazitaxel Treatment in Metastatic Castration-Resistant Prostate Cancer.

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A method is presented to radiobiologically compare sequential (SEQ) and simultaneously integrated boost (SIB) breast radiotherapy. The importance of the management of the ocular surface in MMP is briefly summarised. Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth cardisan drug factor I, and insulin-like growth factor-binding protein 3. Furthermore, the need to promote public health and fitness through the Olympics is re-emphasised.

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In vitro kinase assays established that protein kinase A (PKA) directly phosphorylates the T207 phospho-site. Towards quantifying the glacial runoff signal campal goa hotels in india in the freshwater input to Tyrolerfjord-Young Sound, NE Greenland.

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Little is known about the interrelationship between the lipid profile, cholesterol metabolism, and coronary risk factors in patients with hemodialysis (HD) in the presence or absence of coronary artery disease (CAD). Inspired by the use of plastic food wrap, this study proposes the use of polymer thin films (also known as nanosheets) to fix the tissue samples. This study aims to investigate whether the Guillotine Sluder operation techniques is ideal in a limited resource developing country setting. In this study, spatial control of mineralization was achieved in collagen buspirone hcl 15 mg price matrices using simulated body fluids (SBFs). Acquired hemophilia A (AHA) is a disorder characterized by bleeding caused by autoantibodies that are developed against factor VIII.

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Yeast submitochondrial particles, in a Pi- and NADH-dependent reaction, produced low acyclovir prophylaxis pregnant dosage calculator concentrations of free ATP in the absence of added ADP. Pulse-chase analyses of r-proteins in myoblasts and fibers indicate that the synthesis of r-proteins is coordinately reduced 2.0-fold following myoblast differentiation and that newly synthesized r-proteins do not turnover. Achievements have been made in the optimization of aptamer libraries, separation schemes, amplification of the selected libraries and the identification of aptamer sequences from enriched libraries. In the current review we will discuss these agents with focus on their potential clinical uses and limitations. Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study.

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The development of a new system for measuring the deformability of isolated erythrocyte membranes is described. Exploring misinformation of family planning practices and methods among deaf people in Ghana. Such an approach has generated a number of drug combinations, such as sequential MTX-5FU, with widely applicable clinical efficacy. The isoepoxydon dehydrogenase gene of the patulin metabolic pathway differs for Penicillium griseofulvum and Penicillium expansum. Whereas the amplification trimethoprim-sulfamethoxazole other drugs in same class as tramadol products of DOP-PCR were immediately available for labeling and hybridization, the products of MDA required a further digestion step to produce optimal-sized probes for CGH.

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The pharmacokinetic parameters indicated that both erlotinib and icotinib are affected by food. To investigate the hypothesis that increased formation of reactive nitrogen species may contribute to terazosin dosage forms for geriatric patients the vascular pathology that develops in patients with connective tissue disease such as scleroderma. Our results clearly show that the gene-rich regions are prevalently located in the few microchromosome pairs and in the telomeric regions of the middle-sized chromosomes, as well as in the interior of the interphase nuclei.